Diabetes and camel milk more details

Diabetes and camel milk more details

 

Experimental Evidences of Therapeutic Effects of Camel Milk on IDDM

 

Patients with type 1 diabetes suffer chronic hyperglycemia and dysfunction of carbohydrates, fat and protein metabolism.

Effect of camel milk in comparison to cow’s milk on blood glucose, triglycerides, alanine-amino transferase (ALT) and asparate amino transferase (AST) levels in healthy female albino rats was studied .

At the end of the study period, rat blood samples were analyzed.

No significant difference in glucose, triglyceride, AST and ALT activity was detected between the control and treated groups.

But cholesterol levels of both 100% cow and 100% camel milk treated rats were shown to be significantly lesser than control group.

It can be concluded from this study that camel milk can be safely consumed by non-diabetics or healthy individuals.

Study to analyze the anti-diabetic effects of camel milk in streptozotocin-induced diabetic rats by assaying liver and kidney clinical function parameters was conducted .

Administration of streptozotocin to the experimental groups of rats resulted in marked detectable changes.

The rats were fed daily with fresh camel milk for 30 days. The effects of camel milk on blood glucose, serum proteins, blood urea, uric acid, creatinine, lipid profile and the activities of diagnostic marker enzymes of liver and alkaline phosphatase (ALP) in the plasma/serum of control and experimental groups of rats were evaluated.

The results of this study showed that, camel milk feeding to diabetic rats significantly reduces the levels of blood glucose, urea, uric acid and creatinine and increases the activities of albumin, albumin/ globulin ratio and restores all liver function marker enzymes and lipid profile to near control levels.

The data of this study demonstrated that camel milk has anti-hyperglycemic effects and alleviate liver and renal damage associated with streptozotocin-induced diabetic mellitus.
The hypoglycemic effect of camel milk in comparison to cow and buffalo milks in stretozotocin-induced diabetic rats was carried out.

The effects of camel, cow and buffalo milks on liver and kidney functions of the diabetic rats in comparison to a control group and groups fed with cow and buffalo milks were also investigated.

The study revealed that, camel milk was most effective in hypoglycemic control of the diabetic rats; it reduced hyperglycemia by 49.2%, while cow and buffalo milks reduced hyperglycemia by 11.6% and 11.1% respectively. Also, camel milk improved liver enzyme functions of alanine-amino transferase and aspartate amino transferase by 41 and 38% respectively compared to cow and buffalo milk fed diabetic group.
Also, camel milk showed significant normalization effects in blood uric acid, urea, and creatinine of the diabetic study group.

The findings of this study demonstrated that, camel milk has marked glycemic control and positive effects on liver and renal functions of diabetic subjects. Effect of oral insulin carried by camel milk on type 1 diabetes patients in comparison with both insulin injection requirements and camel milk alone was studied . Fifty randomly selected type 1 diabetic patients were divided into three groups; A, B and C. Group B in addition to usual care received 0.5 L of camel milk daily, while group C in addition to usual care received insulin mixed with 0.5 L ml of camel milk daily. Results of this study showed significant improvements in fasting blood sugar, post parandial blood sugar, HbA1c and significant reduction in insulin requirement in group C receiving insulin mixed with camel’s milk in comparison with groups A and B. This study proved that camel milk mixed with insulin was effective supplementation, as adjunctive therapy in management of type 1 diabetes.

Results

Proteolysis sites of digestive proteases in different types of insulin of different species. Models of human and camel insulin are essentially the same as predicted by I-TASSER . We hypothesized that camel insulin is protected
from digestive enzymes in the stomach and thus absorbed in the intestine. The numbers of calculated cut sites for different types of insulin were the same for camel, human, bovine, goat, buffalo, sheep and pig insulin (Table I). The preferred cut sites
for pepsin are Phe, Tyr, Trp and Leu. Trypsin prefers Arg and Lys at P1 while chymotrypsin preferentially cleaves at Trp, Tyr and Phe in position P1 (high specificity) and to a lesser extent at Leu, Met and His (low specificity). Camel insulin differs from
human insulin by four mutations and from bovine and buffalo by just one mutation. None of the mutations affect specificity toward digestive enzymes. Therefore, camel insulin should be identical to human, bovine, buffalo, goat, sheep and pig insulin
in terms of susceptibility toward proteolysis. Thus, when camel insulin comes in contact with the proteases of digestive track it should be digested like other mammalian insulin unless otherwise protected.

The presentation of the properties and potential benefits of camel milk on this site is based on scientific research, laboratory tests and consumer experiences.

This is in no way a medical opinion